Author

Nicholas Wightman

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Robert H. BrowniD· 3 shared Alexandra Weiss· 2 shared Alexander JaworskiiD· 1 shared Allana Schooley· 1 shared Alper KüçükuraliD· 1 shared Anastasia KhvorovaiD· 1 shared Ashley L. HarkinsiD· 1 shared Ashley SummersiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Robert H. BrownORCID

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3 papers

Recent·Most cited

Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons

Özgün Uyan, Snehal Sambare, Marlies E. Oomen, Nicholas Wightman, Allana Schooley, Joseph R. Klim, Houda Belaghzal, Özkan Aydemir, Betül Akgöl Oksuz, Zeynep Sena AGIM USLU, Kevin C. Eggan, Robert H. Brown, Job Dekker

The paper examines changes in chromosome conformation, nuclear organization, and transcription during motor neuron maturation in control and ALS C9orf72 mutant cells, finding delayed maturation in disease models.

bioRxiv · Sep 22, 2025 · PreprintNeuroscience

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Alexandra Weiss, James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal M. Ferguson, Elif O. Dogan, Nicholas Wightman, Kit Mocarski, Dimas Echeverria, Ashley L. Harkins, Ashley Summers, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Nozomi Yamada, , Anastasia Khvorova

The paper shows that silencing SOD1 with optimized di-siRNA extends survival and prevents disease progression in ALS mice.

Molecular Therapy · May 9, 2025Peer-reviewedNeuroscience

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in Sod1 mutant mouse model of ALS.

Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt, Katerina Rademacher, Kristin M. Webster, Hesheng Zhang, Haruhiko Banno, Siqi Tang, Yifan Zhang, Nicholas Wightman, Emma M. Shychuck, John Page, Alexandra Weiss, Karen L. Kelly, Alper Küçükural, , Robert H. Brown

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.

bioRxiv · May 5, 2023 · PreprintNeuroscience