BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II
Monika Mačáková, Cassidy Danyko, Stefan Oberlin, Tam Binh V Bui, Otto Kauko, Houqing Yin, Yuqing Bai, Caroline C. Friedel, Heidi M. Haikala, Anniina Vihervaara, Jennifer M. Rosenbluth, Michael T. McManus, Steven Henikoff, Matjaž Barborič
The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.
bioRxiv · Aug 26, 2026 · PreprintMolecular Biology