Author

Heidi M. Haikala

University of HelsinkiORCID 0000-0002-8465-8568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Otto KaukoiD· 2 shared Anniina VihervaaraiD· 1 shared Caroline C. FriedeliD· 1 shared Cassidy DanykoiD· 1 shared Houqing Yin· 1 shared Iman Khani FarahaniiD· 1 shared Jenna H. RannikkoiD· 1 shared Jennifer M. RosenbluthiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Otto KaukoORCID

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2 papers

Recent·Most cited

BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II

Monika Mačáková, Cassidy Danyko, Stefan Oberlin, Tam Binh V Bui, Otto Kauko, Houqing Yin, Yuqing Bai, Caroline C. Friedel, Heidi M. Haikala, Anniina Vihervaara, Jennifer M. Rosenbluth, Michael T. McManus, Steven Henikoff, Matjaž Barborič

The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.

bioRxiv · Aug 26, 2026 · PreprintMolecular Biology

YAP/TEAD drives treatment-induced adaptive immunosuppression in EGFR-mutant lung cancer

Meija Honkanen, Jonas Baumgarten, Nikol Dibus, Jenna H. Rannikko, Miloš Gojković, Paloma Cejas, Yingtian Xie, Zsuzsanna Ortutay, Johannes A. M. Merilahti, Mari Tienhaara, Iman Khani Farahani, Steffen Boettcher, Pasi Antero Janne, Otto Kauko, Raphael A. Nemenoff, , Kari J. Kurppa

This study shows that DTP cells in EGFR-mutant lung cancer drive immunosuppression through YAP/TEAD activity, and co-targeting YAP/TEAD improves EGFR TKI therapy efficacy.

bioRxiv · Jan 24, 2026 · PreprintCancer Biology