Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes
Rédouane Aherrahrou, Dillon Lue, R. Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan, Joon Yuhl Soh, Tiit Örd, Prosanta Singha, Huda Gilani, Ernest Diez Benavente, Doris Wong, Jameson Hinkle, Lijiang Ma, Gloria Sheynkman, Hester M. den Ruijter, , Mete Civelek
The paper identifies eQTLs and sQTLs in human aortic SMCs that colocalize with CAD GWAS loci, highlighting splicing regulation as a mechanism for CAD risk.
bioRxiv · Jan 24, 2022 · PreprintGenetics