Rédouane Aherrahrou

Deficiency of ZC3HC1 modulates vascular smooth muscle cell phenotype and increases neointima formation

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

Network preservation analysis reveals dysregulated metabolic pathways in human vascular smooth muscle cell phenotypic switching

The paper identifies dysregulated metabolic pathways in vascular smooth muscle cells during phenotypic switching and links them to atherosclerosis.

FHL5 controls vascular disease-associated gene programs in smooth muscle cells

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.

Genetic Regulation of Circular RNA Expression in Human Aortic Smooth Muscle Cells and Vascular Traits

This study identifies circRNA expression patterns and genetic associations in human aortic smooth muscle cells and links them to cardiovascular traits.

Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes

The paper identifies eQTLs and sQTLs in human aortic SMCs that colocalize with CAD GWAS loci, highlighting splicing regulation as a mechanism for CAD risk.