Mete Civelek

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

The paper examines sex-specific regulation of EndMT in atherosclerosis using bulk RNA-seq and single-cell transcriptomics, identifying key regulators and stage-dependent differences.

The paper investigates how impaired mechanoperception in lung fibroblasts affects gene expression programs, revealing a link between integrin signaling and HOXA5 silencing in lung development and regeneration.

This study shows 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility in adipose precursor cells, impacting gene expression and fat mass.

The paper identifies female-biased VSMC gene regulatory networks and highlights MYH9 as a key regulator of fibrous plaque phenotype in females.

The paper develops a computational model of cardiac proliferation signaling that identifies key regulators and predicts Hippo to cMyc module crosstalk driving cardiomyocyte proliferation.

This study identifies CAD-associated variants regulating vascular smooth muscle cell gene expression through functional assays and eQTL integration.

The paper identifies key driver genes affecting adipocyte function and body fat distribution using systems genetics and experimental validation.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

The paper identifies dysregulated metabolic pathways in vascular smooth muscle cells during phenotypic switching and links them to atherosclerosis.

The paper identifies genetic variants with discordant effects on type 2 diabetes and abdominal obesity and proposes potential mechanisms for these effects.

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.

This study identifies circRNA expression patterns and genetic associations in human aortic smooth muscle cells and links them to cardiovascular traits.

The paper identifies eQTLs and sQTLs in human aortic SMCs that colocalize with CAD GWAS loci, highlighting splicing regulation as a mechanism for CAD risk.

The paper compares regression, IPW, and g-formula methods for estimating exposure effects on gene expression, applying them to assess smoking's impact on adipose tissue gene expression.

The paper introduces an R package to infer primary transcript annotations from run-on data, improving sensitivity in detecting differentially expressed transcripts and RNA polymerase pause indices.

This study identifies a genetic variant at 1p32.2 that regulates endothelial responses to hemodynamics by modulating an enhancer region in vascular endothelium.

BART predicts functional transcription factors regulating a gene set or associated with a genomic profile using existing ChIP-seq data.

The paper identifies DNA methylation associations with metabolic syndrome traits in adipose tissue and develops a biomarker for type II diabetes risk.

The paper integrates gene expression and GWAS data to identify novel genes associated with obesity-related traits.