Author

Huei-Mei Chen

Primary ORCID profile (0000-0002-3391-8542 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Huei-Mei CheniD2 papers · Harvard University

Biology Disciplines

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Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam S. Lazorchak· 1 shared Amy Lundberg· 1 shared Andrew Pla· 1 shared Anja F. Hohmann· 1 shared C D Malloy· 1 shared Cagdas Tazearslan· 1 shared Caroline P. Bullock· 1 shared Charuta Yadav· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPharmacology & Toxicology

Adam S. Lazorchak

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2 papers

Recent·Most cited

A Precision Gene Engineered B Cell Medicine Producing Sustained Levels of Active Factor IX for Hemophilia B Therapy

Hanlan Liu, Swati Singh, Timothy Mullen, Caroline P. Bullock, Sean Keegan, Troy Patterson, Sakshisingh Thakur, Amy Lundberg, Sol Shenker, Ryan Couto, Charuta Yadav, Shamael R. Dastagir, Lily Yuanzhi Li, Wayne Bainter, Ella Liberzon, , Richard A. Morgan

This paper describes a gene-engineered B Cell Medicine (BE-101) that produces sustained active factor IX for hemophilia B therapy, showing durable and redosable effects in mice.

Molecular Therapy · Sep 5, 2025Peer-reviewedPharmacology & Toxicology

Genome-wide assays to characterize rAAV integration into human genomic DNA in vivo

Jaime Prout, Jessica R. Von Stetina, Gustavo Cerqueira, Madison Chasse, Huei-Mei Chen, Andrew Pla, Rachel Resendes, Danielle Sookiasian, Cagdas Tazearslan, Jason B. Wright, John F. Thompson

The paper develops long-read sequencing assays to detect on- and off-target integration of rAAV vectors in human genomic DNA, finding no evidence of off-target integration.

bioRxiv · Aug 22, 2023 · PreprintGenomics