Author

Huei-Mei Chen

Harvard UniversityORCID 0000-0002-3391-8542Unclaimed ORCID profile · follow to get notified of new preprints

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Huei-Mei Chen2 papers

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Beste MutluiD· 3 shared Susan E. MangoiD· 3 shared David H. HalliD· 2 shared Barbara D. OreloiD· 1 shared Bing YangiD· 1 shared E. LevineiD· 1 shared Eleanor M. MaineiD· 1 shared J. Wang· 1 shared

Activity by Year

2018-2018 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersDevelopmental Biology

Beste MutluORCID

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3 papers

Recent·Most cited

MET-2, a SETDB1 family methyltransferase, coordinates embryo events through distinct histone H3 methylation states

Beste Mutlu, Huei-Mei Chen, David H. Hall, Susan E. Mango

The paper shows MET-2, a methyltransferase, coordinates embryo development by distinct H3K9 methylation states, linking heterochromatin formation to loss of developmental potential.

bioRxiv · Oct 1, 2018 · PreprintDevelopmental Biology

A heterochromatic histone methyltransferase lowers nucleosome occupancy at euchromatic promoters

H.M. Chen, T.B. Sackton, B. Mutlu, J. Wang, S. Keppler-Ross, E. Levine, T. Liu, S.E. Mango

This study shows that H3K9me3 prevents nucleosome deposition at euchromatic promoters, affecting gene expression in C. elegans.

bioRxiv · Sep 27, 2018 · PreprintDevelopmental Biology

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos

Beste Mutlu, Huei-Mei Chen, James J. Moresco, Barbara D. Orelo, Bing Yang, John M. Gaspar, Sabine Keppler‐Ross, John R. Yates, David H. Hall, Eleanor M. Maine, Susan E. Mango

The paper shows that MET-2/SETDB1 and its interactors LIN-65/ATF7IP and ARLE-14/ARL14EP regulate the timing of heterochromatin formation during C. elegans embryogenesis.

Science Advances · Aug 3, 2018Peer-reviewedDevelopmental Biology