Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module
Ti‐Chun Chao, Shin-Fu Chen, Hee Jong Kim, Hui-Chi Tang, Hsiang-Ching Tseng, An Xu, Leon Palao, Subash Khadka, Tao Li, Mo-Fan Huang, Dung‐Fang Lee, Kenji Murakami, Thomas Boyer, Kuang‐Lei Tsai
This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.
Molecular Cell · Sep 24, 2024Peer-reviewedBiochemistry