BiochemistryMolecular CellPeer-reviewed
Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module
Ti‐Chun Chao, Shin-Fu Chen, Hee Jong Kim…·Kuang‐Lei Tsai
This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.