Author

Kenji Murakami

University of PennsylvaniaORCID 0000-0002-2017-5575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Hee Jong KimiD· 2 shared An XuiD· 1 shared Christopher R. BrueiD· 1 shared Dung‐Fang LeeiD· 1 shared Elizabeth R. RhoadesiD· 1 shared Hsiang-Ching TsengiD· 1 shared Hui-Chi Tang· 1 shared Karen AcostaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Hee Jong KimORCID

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2 papers

Recent·Most cited

Structural Insights into the Role of the Proline Rich Region in Tau Function

Karen Acosta, Christopher R. Brue, Polina Holubovska, Hee Jong Kim, Leland C. Mayne, Kenji Murakami, Elizabeth R. Rhoades

This study investigates how phosphomimic mutations in tau's proline-rich region affect tubulin dimer binding and microtubule polymerization.

Structure · Jan 17, 2025Peer-reviewedBiophysics

Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module

Ti‐Chun Chao, Shin-Fu Chen, Hee Jong Kim, Hui-Chi Tang, Hsiang-Ching Tseng, An Xu, Leon Palao, Subash Khadka, Tao Li, Mo-Fan Huang, Dung‐Fang Lee, Kenji Murakami, Thomas Boyer, Kuang‐Lei Tsai

This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.

Molecular Cell · Sep 24, 2024Peer-reviewedBiochemistry