Author

Kuang‐Lei Tsai

The University of Texas Health Science Center at HoustonORCID 0000-0002-5428-4219Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

An XuiD· 1 shared Askar M. AkimzhanoviD· 1 shared Chorong Han· 1 shared Dung‐Fang LeeiD· 1 shared Hee Jong KimiD· 1 shared Hsiang-Ching TsengiD· 1 shared Hui-Chi Tang· 1 shared Hyun Kyoung LeeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

An XuORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 22, 2026

DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock

Ji Ye Lim, Shayahati Bieerkehazhi, Chorong Han…·Seung Hee Yoo

This study identifies S-acylation of CRY1 as a critical post-translational modification regulated by DHHC3, essential for its nuclear localization and repressor function in the circadian clock.

DOI 10.64898/2026.05.20.726662

humanproteomics

𝕏 PostBluesky

BiochemistryMolecular CellPeer-reviewedSep 24, 2024

Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module

Ti‐Chun Chao, Shin-Fu Chen, Hee Jong Kim…·Kuang‐Lei Tsai

This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.

33 citationstop 5%

humancryo-EM

𝕏 PostBluesky