Xinwen Chen

The S1B-Targeting PEDV Neutralizing Antibody C62 Prematurely Activates S-trimer and Mimics Receptor Function

This study determines the structure of PEDV S1B bound by neutralizing and non-neutralizing antibodies, revealing how C62 targets a conserved epitope and influences viral entry and neutralization.

A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213-UBE2J2 complex

This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.

The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in Mycobacterium abscessus

This study identifies SigH as a key regulator of intrinsic antibiotic resistance in Mycobacterium abscessus through transcriptomic analysis and genetic complementation.

Enhanced Target Binding by Leritrelvir Restores Dimerization of Mpro Mutants and Mitigates Drug Resistance

This study evaluates leritrelvir's effectiveness against Mpro variants with resistance mutations, showing it restores dimerization and maintains inhibitory activity better than nirmatrelvir.

Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to Rhinolophus cornutus Bat ACE2 and Constraints on Switching to Human ACE2

This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.

Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escape

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection

This study identifies HGS as a host factor critical for coronavirus infection and discovers RTB as a broad-spectrum antiviral by disrupting HGS-M protein interaction.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

Discovery of resistance-resilient quinoline papain-like protease inhibitors through topology-constrained molecular generative design

This paper discovers a novel quinoline-based PLpro inhibitor, GZNL-2016, that remains effective against drug-resistant SARS-CoV-2 variants like Omicron BA.5 and XBB.1.