RNA exosome-mediated RNA surveillance governs developmental timing in the human cerebellum
Nina A. Barr, Bozhidar Baltov, Rylee E Kang, Jash J Gada, Matthew J. Wade, Ethan N Tjoa, V H Lee, Anoothi Seth, Kafui Dzirasa, Ashleigh E. Schaffer, Hyunmin Kim, Derrick Jerone Morton
This study shows that RNA exosome dysfunction disrupts developmental timing and lineage fidelity in human cerebellar organoids, leading to neurodevelopmental defects.
bioRxiv · Oct 16, 2026 · PreprintMolecular Biology