Targeting Wnt Signaling To Overcome PARP Inhibitor Resistance
Tomomi M. Yamamoto, Alexandra McMellen, Zachary L. Watson, Jennifer Aguilera, Matthew J. Sikora, Rebecca Ferguson, Elmar Nurmemmedov, Tanay Thakar, George-Lucian Moldovan, Hyunmin Kim, Diana M. Cittelly, Heidi Wilson, Kian Behbakht, Benjamin G. Bitler
This study identifies Wnt signaling activation as a mechanism of PARP inhibitor resistance in HGSOC and shows that combining PARPi with Wnt inhibitors reduces tumor burden.
bioRxiv · Jul 27, 2018 · PreprintCancer Biology