Author

I. A. P. Thompson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 8 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1

Frequent Co-Authors

H. T. Soh· 9 shared M. Eisenstein· 8 shared N. Maganzini· 5 shared A. A. Hariri· 4 shared J. Pan· 3 shared A. P. Cartwright· 2 shared C. Dory· 2 shared L. Zheng· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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9 shared papersBioengineering

H. T. Soh

Mutual co-authors in cluster

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9 papers

Recent·Most cited

Aptamer-antibody chimera sensors for sensitive, rapid and reversible molecular detection in complex samples

D. Kong, N. Maganzini, I. A. P. Thompson, M. Eisenstein, H. T. Soh

This paper introduces PANDAS, a sensor combining antibodies and aptamers for sensitive, rapid, and reversible molecular detection in complex samples, achieving 100-fold improved sensitivity for thrombin detection.

bioRxiv · Aug 8, 2023Bioengineering

Real-Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch-Conjugated Hydrogel Matrix

C. H. Park, I. A. P. Thompson, S. S. Newman, L. A. Hein, X. Lian, K. Fu, J. Pan, M. Eisenstein, H. T. Soh

The paper develops a hydrogel-based sensor to measure extracellular signaling molecules in real-time and demonstrates its use for cAMP in Dictyostelium discoideum.

bioRxiv · Jul 9, 2023Bioengineering

A rapid ELISA platform with no sample preparation requirement

N. Maganzini, A. Reschke, A. Cartwright, Y. Gidi, I. A. P. Thompson, A. A. Hariri, C. Dory, Y. Rosenberg-Hasson, J. Pan, M. Eisenstein, T. Cornell, H. T. Soh

This paper introduces a rapid ELISA platform that requires no sample preparation, enabling quick quantification of protein biomarkers in blood samples.

bioRxiv · Apr 14, 2023 · PreprintBioengineering

An Antibody-Based Molecular Switch for Continuous Biosensing

I. A. P. Thompson, J. Saunders, L. Zheng, A. A. Hariri, N. Maganzini, A. P. Cartwright, J. Pan, M. Eisenstein, H. T. Soh

This paper introduces an antibody-based molecular switch for continuous biosensing of biomarkers without sample preparation, demonstrating real-time detection of digoxigenin and cortisol with adjustable sensitivity.

bioRxiv · Mar 7, 2023 · PreprintBioengineering

Continuous optical detection of small-molecule analytes in complex biomatrices

A. A. Hariri, A. P. Cartwright, C. Dory, Y. Gidi, S. Yee, K. X. Fu, K. Yang, D. Wu, I. A. P. Thompson, N. Maganzini, T. Feagin, B. E. Young, B. H. Afshar, M. Eisenstein, M. Digonnet, , H. T. Soh

This paper introduces an optical biosensor system for continuous detection of biomarkers in complex samples, achieving high sensitivity and long-term monitoring of dopamine and cortisol.

bioRxiv · Mar 3, 2023 · PreprintBiophysics

A modular intramolecular triplex photo-switching motif that enables rapid and reversible control of aptamer binding activity

T. Trinh, I. A. P. Thompson, F. Clark, J. M. Remington, M. Eisenstein, J. Li, H. T. Soh

This paper designs a DNA-based photoswitch that enables rapid and reversible control of aptamer binding activity through azobenzene isomerization.

bioRxiv · May 22, 2022 · PreprintBioengineering

Pre-equilibrium biosensors: A new approach towards rapid and continuous molecular measurements

N. Maganzini, I. A. P. Thompson, B. Wilson, H. T. Soh

This paper introduces a pre-equilibrium biosensor method to rapidly and sensitively measure ligand concentrations before equilibrium, demonstrating its application to continuous insulin monitoring.

bioRxiv · Mar 26, 2022 · PreprintBioengineering

Rational Design of Aptamer Switches with Programmable pH Response

I. A. P. Thompson, L. Zheng, M. Eisenstein, H. T. Soh

This paper introduces a method to create pH-responsive aptamer switches by inserting orthogonal motifs, enabling tunable affinity changes across different pH conditions.

bioRxiv · Mar 14, 2020Bioengineering

Independent Control of the Thermodynamic and Kinetic Properties of Aptamer Switches

B. D. Wilson, A. A. Hariri, I. A. P. Thompson, M. Eisenstein, H. T. Soh

This study introduces a design strategy to independently control the thermodynamic and kinetic properties of aptamer switches, enabling adjustable sensitivity and temporal resolution.

bioRxiv · Jul 2, 2019Bioengineering