K. Fu

Differentiating erythroblasts adapt to turbulent flow by accelerating maturation and activating cholesterol biosynthesis.

This study shows that erythroblasts adapt to shear stress by accelerating maturation and upregulating cholesterol biosynthesis, enhancing osmotic resistance and enucleation.

Real-Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch-Conjugated Hydrogel Matrix

The paper develops a hydrogel-based sensor to measure extracellular signaling molecules in real-time and demonstrates its use for cAMP in Dictyostelium discoideum.

Transcriptomic profiling of the adult reptilian dentition sheds light on the genes regulating indefinite tooth replacement

This study profiles the transcriptome of adult lizard teeth to identify genes regulating indefinite tooth replacement, finding SEMA3A and SFRP2 may be involved in tooth resorption and eruption.

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.

Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers

This paper demonstrates a method to distinguish and quantify chemically similar small molecules using electrochemical aptamers by tuning surface charge.

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals

This paper develops an implantable sensor to monitor drug pharmacokinetics in tumor tissue in live animals, showing differences from systemic circulation that impact drug efficacy and safety.

Accelerated electron transfer in nanostructured electrodes improves the sensitivity of electrochemical biosensors

This study identifies a mechanism by which nanostructured electrodes enhance electrochemical biosensor sensitivity through accelerated electron transfer, achieving up to 24-fold signal increase and four-fold lower limit-of-detection.

Length-dependent accumulation of double-stranded RNAs in plastids affects RNA interference efficiency in the Colorado potato beetle

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.