Author

I. Bruzual

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

A. Nilsen· 2 shared M. K. Riscoe· 2 shared R. W. Winter· 2 shared S. Pou· 2 shared A. Krollenbrock· 1 shared A. Miller· 1 shared B. K. Wilder· 1 shared D. J. Hinrichs· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Nilsen

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2 papers

Recent·Most cited

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

J. S. Doggett, T. L. Schultz, A. Miller, I. Bruzual, S. Pou, R. W. Winter, R. Dodean, L. N. Zakharov, A. Nilsen, M. K. Riscoe, V. B. Carruthers

This study develops an orally bioavailable prodrug of ELQ-316 that enhances its plasma concentrations and efficacy against Toxoplasma gondii infection.

bioRxiv · Mar 19, 2020Pharmacology & Toxicology

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

M. J. Smilkstein, S. Pou, A. Krollenbrock, L. A. Bleyle, R. A. Dodean, L. Frueh, D. J. Hinrichs, Y. Li, T. Martinson, M. Y. Munar, R. W. Winter, I. Bruzual, S. Whiteside, A. Nilsen, D. R. Koop, , M. K. Riscoe

This paper evaluates ELQ-331 as a long-acting injectable chemoprotective agent against malaria, showing it provides durable protection in mice for up to 4.5 months.

bioRxiv · Jul 2, 2019Pharmacology & Toxicology