Author

M. J. Smilkstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:mouse· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

M. K. Riscoe· 2 shared A. B. Vaidya· 1 shared A. Krollenbrock· 1 shared A. Nilsen· 1 shared B. K. Wilder· 1 shared C. Luck· 1 shared D. J. Hinrichs· 1 shared D. R. Koop· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

M. K. Riscoe

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2 papers

Recent·Most cited

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

M. J. Smilkstein, S. Pou, A. Krollenbrock, L. A. Bleyle, R. A. Dodean, L. Frueh, D. J. Hinrichs, Y. Li, T. Martinson, M. Y. Munar, R. W. Winter, I. Bruzual, S. Whiteside, A. Nilsen, D. R. Koop, , M. K. Riscoe

This paper evaluates ELQ-331 as a long-acting injectable chemoprotective agent against malaria, showing it provides durable protection in mice for up to 4.5 months.

bioRxiv · Jul 2, 2019Pharmacology & Toxicology