Author

M. K. Riscoe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. Pou· 5 shared A. Nilsen· 4 shared R. W. Winter· 4 shared J. S. Doggett· 3 shared M. W. Mather· 3 shared R. Dodean· 3 shared A. B. Vaidya· 2 shared H. Ke· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

S. Pou

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Babesia duncani as a model organism to study the development, virulence and drug susceptibility of intraerythrocytic parasites in vitro and in vivo

C. Mamoun, A. C. Pal, I. Renard, P. Singh, P. Vydyam, J. E. Chiu, S. Pou, R. W. Winter, R. Dodean, L. Frueh, A. C. Nilsen, M. K. Riscoe, J. S. Doggett

This paper establishes a new in vitro and in vivo model using Babesia duncani to study parasite development, virulence, and drug susceptibility, identifying effective new therapies.

bioRxiv · Dec 1, 2021Microbiology

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

J. E. Chiu, I. Renard, A. Chattopadhyay Pal, P. Singh, P. Vydyam, J. Thekkiniath, M. Kumar, S. Gihaz, S. Pou, R. W. Winter, R. Dodean, A. Nilsen, M. K. Riscoe, J. S. Doggett, C. Ben Mamoun

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

bioRxiv · Mar 31, 2021Microbiology

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

J. S. Doggett, T. L. Schultz, A. Miller, I. Bruzual, S. Pou, R. W. Winter, R. Dodean, L. N. Zakharov, A. Nilsen, M. K. Riscoe, V. B. Carruthers

This study develops an orally bioavailable prodrug of ELQ-316 that enhances its plasma concentrations and efficacy against Toxoplasma gondii infection.

bioRxiv · Mar 19, 2020Pharmacology & Toxicology

Genetic ablation of the mitochondrial ribosome in Plasmodium falciparum sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functions

L. Ling, M. Mulaka, J. Munro, S. Dass, M. W. Mather, M. K. Riscoe, M. Llinas, J. Zhou, H. Ke

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

M. J. Smilkstein, S. Pou, A. Krollenbrock, L. A. Bleyle, R. A. Dodean, L. Frueh, D. J. Hinrichs, Y. Li, T. Martinson, M. Y. Munar, R. W. Winter, I. Bruzual, S. Whiteside, A. Nilsen, D. R. Koop, , M. K. Riscoe

This paper evaluates ELQ-331 as a long-acting injectable chemoprotective agent against malaria, showing it provides durable protection in mice for up to 4.5 months.

bioRxiv · Jul 2, 2019Pharmacology & Toxicology

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

H. Ke, S. M. Ganesan, S. Dass, J. M. Morrisey, S. Pou, A. Nilsen, M. K. Riscoe, M. W. Mather, A. B. Vaidya

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.

bioRxiv · Oct 5, 2018Microbiology