V. B. Carruthers

A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs

This study uses the AsGM1 membrane lipid signature to distinguish NK cells and ILC1s, capturing their plasticity across tissues and conditions.

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma

The paper identifies a conserved microneme protein complex, CLAMP-SPATR-CLIP, essential for rhoptry discharge in Toxoplasma gondii.

Stable and ancient endocytic structures navigate the complex pellicle of apicomplexan parasites

This study identifies stable endocytic structures in Toxoplasma, showing their conservation across Apicomplexa and their role in plasma membrane homeostasis rather than nutrition.

Toxoplasma scavenges mammalian host organelles through usurpation of host ESCRT-III and Vps4

This study shows Toxoplasma uses host ESCRT-III and Vps4 to scavenge host organelles into its parasitophorous vacuole through proteins TgGRA14 and TgGRA64.

Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress

This paper directly measures pH changes in the parasitophorous vacuole during Toxoplasma gondii egress and identifies formate-nitrite transporters as contributors to vacuolar acidification.

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during Toxoplasma gondii infection

This study identifies GRA64, a Toxoplasma gondii dense granule protein that interacts with host ESCRT proteins, and shows its role in intracystic vesicle formation during chronic infection.

Toxoplasma gondii subverts the host ESCRT machinery for parasite uptake of host cytosolic proteins

This study identifies TgGRA14 as a parasite protein that recruits the host ESCRT machinery to facilitate uptake of host cytosolic proteins across the parasitophorous vacuole membrane.

Toxoplasma gondii Toxolysin 4 contributes to efficient parasite egress from host cells

This study identifies Toxolysin 4 (TLN4) as a metalloproteinase necessary for efficient Toxoplasma gondii egress from host cells.

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites

This study shows that Toxoplasma gondii bradyzoites can internalize host-derived cytosolic mCherry across the cyst wall.

Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion

This paper investigates the role of phosphorylation in regulating the localization of two secreted Toxoplasma proteins during stage conversion and identifies widespread differential phosphorylation of secreted proteins.

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

This study develops an orally bioavailable prodrug of ELQ-316 that enhances its plasma concentrations and efficacy against Toxoplasma gondii infection.

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 play recessive roles in endolysosomal protein digestion during infection

This study shows that CPL is the dominant protease in Toxoplasma gondii's VAC, while CPB and ASP1 have dispensable roles in protein digestion.

A role for Toxoplasma gondii chloroquine resistance transporter in bradyzoite viability and digestive vacuole maintenance

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

This study identifies the structural basis of TgPLP1 membrane interaction and its role in parasite egress by showing a hydrophobic loop insertion into the membrane is essential for cytolytic activity.