I. C. Guerrera

The PP1 phosphatase exhibits pleiotropic roles controlling both the tachyzoite cell cycle and amylopectin-steady state levels in Toxoplasma gondii.

This study shows that TgPP1 regulates the tachyzoite cell cycle and amylopectin levels in Toxoplasma gondii through post-transcriptional mechanisms.

Characterization of the Plasmodium berghei regulatory AAA-ATPase subunit Rpt3 as an activator of Protein Phosphatase 1: direct and indirect evidence

This paper characterizes PbRpt3 as an activator of Protein Phosphatase 1 in Plasmodium berghei, showing direct and indirect interactions through mutagenesis and Xenopus oocyte models.

Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes

This study shows that IDE deficiency in mice causes a low-level UPR, enhances beta cell proliferation, and protects against autoimmune diabetes through an anti-inflammatory pathway.

Characterization of GEXP15 as a potential regulator of Protein Phosphatase 1 and partner of ribosomal complex in Plasmodium falciparum.

This study identifies GEXP15 as a regulator of PP1 and ribosomal complex in Plasmodium falciparum, enhancing PP1 phosphatase activity and suggesting it as a drug target.

The Pentose Phosphate Pathway constitutes a major metabolic hub in pathogenic Francisella

This study investigates the role of the pentose phosphate pathway in Francisella novicida's intracellular survival and metabolism, showing its critical connections to other metabolic pathways.

Chronic Staphylococcus aureus lung infection correlates with proteogenomic and metabolic adaptations leading to an increased intracellular persistence

This study shows that S. aureus isolates from CF patients have increased intracellular persistence and metabolic adaptations, suggesting an intracellular niche contributes to chronic lung infection.