Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling
B. Czaya, K. Heitman, I. Campos, C. Yanucil, D. Kentrup, D. Westbrook, O. Gutierrez, J. Babitt, G. Jung, I. Salusky, M. Hanudel, C. Faul
This study shows hyperphosphatemia causes inflammation, anemia, and muscle wasting in mice independently of FGF23-FGFR4 signaling, suggesting dietary phosphate restriction may benefit both CKD patients and healthy individuals.
bioRxiv · Oct 22, 2021Cell Biology