Author

I. Coste

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

T. Renno· 4 shared A. Nicolas· 2 shared C. Chaveroux· 2 shared C. Duret· 2 shared C. Ferraro-Peyret· 2 shared J. Fauvre· 2 shared M. Piecyk· 2 shared P.-A. Laval· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCell Biology

T. Renno

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Author profile →

4 papers

Recent·Most cited

Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells

P.-A. Laval, M. Piecyk, P. Le Guen, M. Ilie, J. Fauvre, I. Coste, T. Renno, N. Aznar, C. Hadji, C. Migdal, C. Duret, P. Bertolino, C. Ferraro-Peyret, A. Nicolas, C. Chaveroux

The paper shows that soft extracellular matrix induces S-phase quiescence in progenitor cells via endoplasmic reticulum stress, aligning with molecular traits of pulmonary basal cells.

Acta Biomaterialia · Jul 1, 2024Peer-reviewedCell Biology

Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer.

M. Piecyk, M. Triki, P.-A. Laval, C. Duret, J. Fauvre, L. Cussonneau, C. Machon, J. Guitton, N. Rama, B. Gibert, G. Ichim, F. Catez, F. Bourdelais, S. Durand, J.-J. Diaz, , C. Chaveroux

This study shows GCN2 regulates 47S rRNA synthesis in colon cancer cells under different nutrient conditions, affecting cell survival and response to chemotherapy.

bioRxiv · Feb 8, 2023Cancer Biology

AB668, a novel highly selective protein kinase CK2 inhibitor with a distinct anti-tumor mechanism as compared to CX-4945 and SGC-CK2-1

A. Bancet, R. Frem, F. Jeanneret, A. Mularoni, P. Bazelle, C. Roelants, J.-G. Delcros, J.-F. Guichou, C. Pillet, I. Coste, T. Renno, C. Battail, C. Cochet, T. Lomberget, O. Filhol, I. Krimm

The paper introduces AB668, a selective CK2 inhibitor with a distinct anti-tumor mechanism compared to CX-4945 and SGC-CK2-1, showing apoptotic effects and pathway stimulation in cancer cells.

bioRxiv · Dec 16, 2022 · PreprintBiochemistry

A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-alpha Interaction

R. El Sabeh, M. Bonnet, K. Le Corf, K. Lang, A. Kfoury, B. Badran, N. Hussein, F. Virard, I. Treilleux, M. Le Romancer, S. Lebecque, S. Manie, I. Coste, T. Renno

The paper identifies a gender-dependent molecular switch involving MyD88 and estrogen receptor-alpha that modulates inflammation.

bioRxiv · Jan 31, 2018Immunology