IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation
S. J. Vayttaden, M. Smelkinson, O. Ernst, R. J. Carlson, J. Sun, C. Bradfield, M. G. Dorrington, J. Liang, N. Bouladoux, R. A. Gottschalk, K.-S. Oh, G. Pegoraro, S. Ganesan, D. De Nardo, E. Latz, , I. D. C. Fraser
This study identifies IRAK1-mediated supramolecular organizing centers that coordinate multiple immune pathways to license inflammasome activation in response to microbial signals.
bioRxiv · Dec 26, 2019 · PreprintImmunology