Author

R. A. Gottschalk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:software / tool· 1

Frequent Co-Authors

A. Nita-Lazar· 1 shared B. Marrero· 1 shared C. Bradfield· 1 shared C. J. Bradfield· 1 shared C. T. Boughter· 1 shared D. De Nardo· 1 shared E. Latz· 1 shared G. Pegoraro· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. Nita-Lazar

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Author profile →

3 papers

Recent·Most cited

Macrophages tune responses to pathogen dynamics through TLR4 stimulation memory and by licensing susceptibility to IL-10

H. Bongartz, C. T. Boughter, B. Marrero, T. Prustel, C. J. Bradfield, J. L. Gross, R. A. Gottschalk, A. Nita-Lazar, I. Fraser, M. Meier-Schellersheim

The paper shows macrophages use TLR4 memory and IL-10 susceptibility gating to adjust inflammation based on pathogen dynamics.

bioRxiv · Mar 28, 2024 · PreprintImmunology

Efficient immune cell genome engineering with improved CRISPR editing tools

Waipan Chan, R. A. Gottschalk, Y. Yao, J. Pomerantz, R. N. Germain

Doxycycline-inducible dual-color Cas9, purified lentivirus, puromycin-selected nickase HDR, integrase-deficient lentiviral HDR delivery and an all-in-one CRISPRa vector enable editing of macrophage and Jurkat T cells.

bioRxiv · Feb 13, 2020 · PreprintGenomics✦ In-depth digest

IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation

S. J. Vayttaden, M. Smelkinson, O. Ernst, R. J. Carlson, J. Sun, C. Bradfield, M. G. Dorrington, J. Liang, N. Bouladoux, R. A. Gottschalk, K.-S. Oh, G. Pegoraro, S. Ganesan, D. De Nardo, E. Latz, , I. D. C. Fraser

This study identifies IRAK1-mediated supramolecular organizing centers that coordinate multiple immune pathways to license inflammasome activation in response to microbial signals.

bioRxiv · Dec 26, 2019 · PreprintImmunology