Author

I. Donovan-Banfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:human· 2 Assay:metagenomics· 1

Frequent Co-Authors

J. A. Hiscox· 4 shared R. Penrice-Randal· 3 shared A. Kipar· 2 shared A. Kirby· 2 shared D. F. Mega· 2 shared E. G. Bentley· 2 shared H. Goldswain· 2 shared J. P. Stewart· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

J. A. Hiscox

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.

R. Penrice-Randal, E. G. Bentley, P. Sharma, A. Kirby, I. Donovan-Banfield, A. Kipar, D. F. Mega, C. Bramwell, J. Sharp, A. Owen, J. A. Hiscox, J. P. Stewart

This study examines how molnupiravir and nirmatrelvir affect SARS-CoV-2 genome diversity in immunocompromised mice, finding reduced viral load and specific mutations but no major consensus sequence changes.

bioRxiv · Feb 27, 2024Pharmacology & Toxicology

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

S. Gu, E. G. Bentley, R. I. Milligan, A. M. Almuqrin, P. Sharma, A. Kirby, D. F. Mega, A. Kipar, M. Erdmann, J. Bazire, K. J. Heesom, P. A. Lewis, I. Donovan-Banfield, C. Reston, I. Webb, , D. A. Matthews

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

bioRxiv · Aug 4, 2023 · PreprintMicrobiology

Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance

T. Prince, I. Donovan-Banfield, H. Goldswain, R. Penrice-Randal, C. Hartley, T. Fletcher, S. Khoo, J. A. Hiscox

This study evaluates the antiviral activity of molnupiravir's active metabolite NHC against SARS-CoV-2 variants, finds no resistance after 20 passages, and suggests earlier administration for better efficacy.

bioRxiv · Nov 23, 2021 · PreprintMicrobiology

Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.

J. Zhou, T. P. Peacock, J. C. Brown, D. H. Goldhill, A. M. E. Elrefaey, R. Penrice-Randal, V. M. Cowton, G. De Lorenzo, W. Furnon, W. T. Harvey, R. Kugathasan, R. Frise, L. Baillon, R. Lassauniere, N. Thakur, , W. S. Barclay

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

bioRxiv · Aug 20, 2021 · PreprintMicrobiology