Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
E. C. Bogacki, P. A. Lewis, S. Herbst
This study investigates GPNMB missense mutations in ACD, showing impaired intracellular trafficking and processing, leading to altered secretion and melanosomal function.
bioRxiv · Dec 19, 2023 · PreprintCell Biology
S. Gu, E. G. Bentley, R. I. Milligan, A. M. Almuqrin, P. Sharma, A. Kirby, D. F. Mega, A. Kipar, M. Erdmann, J. Bazire, K. J. Heesom, P. A. Lewis, I. Donovan-Banfield, C. Reston, I. Webb, , D. A. Matthews
This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.
bioRxiv · Aug 4, 2023 · PreprintMicrobiology
L. J. Goudswaard, C. M. Williams, J. Khalil, K. L. Burley, F. Hamilton, D. Arnold, A. Milne, P. A. Lewis, K. J. Heesom, S. J. Mundell, A. D. Davidson, A. W. Poole, I. Hers
This study identifies altered platelet proteome and impaired integrin αIIbβ3 activation in COVID-19 patients, linked to increased platelet-neutrophil aggregates and thromboinflammation.
bioRxiv · Oct 12, 2022 · PreprintCell Biology
Y. Takebayashi, J. Ramos-Soriano, Y. J. Jiang, J. Samphire, E. Belmonte-Reche, M. P. O'Hagan, C. Gurr, K. J. Heesom, P. A. Lewis, T. Samernate, P. Nonejuie, J. Spencer, M. C. Galan
The paper identifies a G-quadruplex ligand, L9, as a potential antibacterial agent against multi-drug resistant E. coli, showing superior activity and distinct mechanism compared to existing ligands.
bioRxiv · Sep 1, 2022 · PreprintMicrobiology
P. A. Lewis, E. Silajdzic, H. Smith, N. Bates, C. A. Smith, D. Knight, C. Denning, D. R. Brison, S. J. Kimber
The paper identifies a proteomic signature associated with early loss of pluripotency in human stem cells and demonstrates its diagnostic potential using multiplexed biomarkers.
bioRxiv · Apr 14, 2021Cell Biology
Y. Takebayashi, J. Samphire, S. A. Hill, N. Hill, K. J. Heesom, P. A. Lewis, D. Alibhai, E. C. Bragginton, J. Dorh, N. Dorh, J. Spencer, M. C. Galan
This paper demonstrates that green fluorescent carbon dots can label and kill Gram-positive and Gram-negative bacteria when combined with LED light exposure.
bioRxiv · Mar 26, 2021Microbiology
J. H. Kluss, A. Beilina, C. D. Williamson, P. A. Lewis, M. R. Cookson, L. Bonet-Ponce
This study shows that lysosomal positioning regulates LRRK2-dependent Rab10 phosphorylation, with phosphatase activity modulating this process in perinuclear lysosomes.
bioRxiv · Dec 1, 2020 · PreprintCell Biology
G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter
This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.
Molecular Metabolism · Oct 1, 2020Peer-reviewedCell Biology
S. Cogo, J. E. Tomkins, N. Vavouraki, V. Giusti, F. Forcellato, C. Franchin, I. Tessari, G. Arrigoni, L. Cendron, C. Manzoni, L. Civiero, P. A. Lewis, E. Greggio
The paper identifies 14-3-3 proteins and PKA-dependent phosphorylation as regulators of spatacsin trafficking, linking them to HSP pathogenesis.
bioRxiv · Sep 9, 2020Cell Biology
A. D. Davidson, M. Kavangh Williamson, S. Lewis, D. Shoemark, M. W. Carroll, K. Heesom, M. Zambon, J. Ellis, P. A. Lewis, J. A. Hiscox, D. A. Matthews
bioRxiv · Mar 22, 2020Microbiology
T. S. Hopes, K. Norris, M. Agapiou, C. G. McCarthy, P. A. Lewis, M. J. O'Connell, J. Fontana, J. L. Aspden
The paper characterizes ribosome heterogeneity in Drosophila melanogaster gonads, showing paralog-switching contributes to specialized ribosome populations that may regulate translation.
bioRxiv · Jan 20, 2020Biochemistry