Author

I. Gruska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

L. Wiebusch· 4 shared B. Bogdanow· 3 shared B. Vetter· 3 shared F. Liu· 2 shared L. Mühlberg· 2 shared A. Dirlam· 1 shared A. Elofsson· 1 shared C. Hagemeier· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

L. Wiebusch

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Author profile →

4 papers

Recent·Most cited

Structural Host-Virus Interactome Profiling of Intact Infected Cells

B. Bogdanow, L. Mühlberg, I. Gruska, B. Vetter, J. Ruta, A. Elofsson, L. Wiebusch, F. Liu

This study introduces SHVIP, a method to identify virus-host PPIs in intact infected cells, revealing 739 PPIs and validating their biological relevance through disruption experiments.

Nature Communications · Jul 21, 2025Peer-reviewedMicrobiology

Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1

G. Vavouras Syrigos, M. Feige, A. Dirlam, R. Businger, I. Gruska, L. Wiebusch, K. Hamprecht, M. Schindler

This study shows that Abemaciclib inhibits HCMV replication by blocking pUL97-mediated SAMHD1 phosphorylation, establishing SAMHD1 as a therapeutic target.

bioRxiv · Feb 1, 2023Microbiology

Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles

B. Bogdanow, I. Gruska, L. Mühlberg, J. Protze, S. Hohensee, B. Vetter, M. Lehmann, L. Wiebusch, F. Liu

The paper maps spatial and functional interactions between virus and host proteins in intact cytomegalovirus particles using cross-linking mass spectrometry and proteomics.

bioRxiv · May 2, 2022Microbiology

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

B. Bogdanow, M. Schmidt, H. Weisbach, I. Gruska, B. Vetter, K. Imami, E. Ostermann, W. Brune, M. Selbach, C. Hagemeier, L. Wiebusch

The paper identifies how herpesvirus kinases interact with Cyclin A to inhibit host DNA synthesis during infection.

bioRxiv · Nov 26, 2019Microbiology