Author

I. Haenelt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

J. M. Silberberg· 2 shared A. Balzulat· 1 shared A. Frank· 1 shared A. Menge· 1 shared A. Schmidtko· 1 shared C. Flauaus· 1 shared C. Paulino· 1 shared C. Stock· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

J. M. Silberberg

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Sensory kinase KdpD is a tandem serine histidine kinase controlling K+ pump KdpFABC on the translational and post-transcriptional level

J. M. Silberberg, S. Ketter, P. J. Boehm, K. Jordan, M. Wittenberg, J. Grass, I. Haenelt

The paper identifies KdpD as a tandem serine histidine kinase that regulates K+ pump KdpFABC through translational and post-transcriptional mechanisms, including serine phosphorylation at high K+ levels.

bioRxiv · Nov 9, 2023 · PreprintMicrobiology

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology

Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC

J. M. Silberberg, R. A. Corey, L. Hielkema, C. Stock, P. J. Stansfeld, C. Paulino, I. Haenelt

The paper investigates ion transport and ATPase coupling in KdpFABC using cryo-EM, biochemical assays, and MD simulations, revealing conserved mechanisms across P-type ATPases.

bioRxiv · May 18, 2021Biophysics

Regulation of lipid saturation without sensing membrane fluidity

S. Ballweg, E. Sezgin, D. Wunnicke, I. Haenelt, R. Ernst

The paper investigates how cells regulate lipid saturation without sensing membrane fluidity by studying the yeast transcriptional regulator Mga2.

bioRxiv · Jul 18, 2019Biophysics