Author

R. Ernst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 5 Organism:yeast· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2

Frequent Co-Authors

J. Reinhard· 3 shared C. Klose· 2 shared C. Mattes· 2 shared G. Hummer· 2 shared H. Stumpf· 2 shared M. Schuldiner· 2 shared R. Covino· 2 shared A. Cadou· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

J. Reinhard

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Remodeling of yeast vacuole membrane lipidomes from the log (1-phase) to stationary stage (2-phases)

J. Reinhard, C. L. Leveille, C. Cornell, A. J. Merz, C. Klose, R. Ernst, S. L. Keller

This paper investigates lipid composition changes in yeast vacuole membranes during growth to quiescence, finding increased phosphatidylcholine with higher melting temperatures.

bioRxiv · Oct 11, 2022Biophysics

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

J. Reinhard, L. Starke, C. Klose, P. Haberkant, H. Hammaren, F. Stein, O. Klein, C. Berhorst, H. Stumpf, J. P. Saenz, J. Hub, M. Schuldiner, R. Ernst

The paper introduces a method to isolate organellar membranes from yeast and uses it to study lipid composition and stress responses in the endoplasmic reticulum and vacuolar membranes.

bioRxiv · Sep 15, 2022Cell Biology

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

I. G. Castro, S. P. Shortill, S. K. Dziurdzik, A. Cadou, S. Ganesan, E. J. Fenech, H. Meyer, A. Fadel, Y. David, M. Davey, C. Mattes, R. Valenti, R. Ernst, V. Zaremberg, T. P. Levine, , M. Schuldiner

The paper systematically analyzes membrane contact sites in yeast to identify new proteins involved in lipid distribution.

bioRxiv · Oct 17, 2021Cell Biology

Cysteine crosslinking in native membranes establishes the transmembrane architecture of Ire1

K. Vaeth, C. Mattes, J. Reinhard, R. Covino, H. Stumpf, G. Hummer, R. Ernst

The paper uses cysteine crosslinking to determine the transmembrane architecture of Ire1 in ER stress signaling, showing an X-shaped configuration independent of stress type.

bioRxiv · Apr 28, 2021Biochemistry

Lipidomic and biophysical homeostasis of mammalian membranes counters dietary lipids perturbations to maintain cellular fitness

K. R. Levental, E. Malmberg, J. L. Symons, Y.-Y. Fan, R. S. Chapkin, R. Ernst, I. Levental

The paper shows that mammalian cells counteract dietary lipid perturbations through lipidomic remodeling to maintain membrane physical properties and cellular fitness.

bioRxiv · Feb 11, 2020Cell Biology

Regulation of lipid saturation without sensing membrane fluidity

S. Ballweg, E. Sezgin, D. Wunnicke, I. Haenelt, R. Ernst

The paper investigates how cells regulate lipid saturation without sensing membrane fluidity by studying the yeast transcriptional regulator Mga2.

bioRxiv · Jul 18, 2019Biophysics

Sexual Dichromatism Drives Diversification Within a Major Radiation of African Amphibians

D. M. Portik, R. C. Bell, D. C. Blackburn, A. M. Bauer, C. D. Barratt, W. R. Branch, M. Burger, A. Channing, T. J. Colston, W. Conradie, J. M. Dehling, R. C. Drewes, R. Ernst, E. Greenbaum, V. Gvozdik, , J. A. McGuire

The paper investigates the evolutionary origins of sexual dichromatism in African reed frogs and finds that dichromatic lineages have double the diversification rate of monochromatic ones.

bioRxiv · Jul 22, 2018Evolutionary Biology

The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1

R. Ernst, M. Gecht, S. Fischer, A. Seybert, A. S. Frangakis, E. Stelzer, R. Covino, G. Hummer, H. F. Hofbauer

This study identifies an amphipathic helix in Opi1 that selectively binds phosphatidic acid over phosphatidylserine, revealing lipid headgroup selectivity in membrane recognition.

bioRxiv · Jan 18, 2018Biochemistry