Author

K. Metzner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Balzulat· 1 shared A. Frank· 1 shared A. K. Beach· 1 shared A. Menge· 1 shared A. S. Englisch· 1 shared A. Schmidtko· 1 shared A. Selmecki· 1 shared B. Halligan· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Balzulat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

P. V. Zande, C. Gautier, N. Kawar, C. Maufrais, K. Metzner, E. Wash, A. K. Beach, R. Bracken, E. I. Maciel, C. M. Fernandes, N. V. Solis, M. Del Poeta, S. G. Filler, J. Berman, I. V. Ene, A. Selmecki

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

bioRxiv · Mar 5, 2024 · PreprintMicrobiology

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology

Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans

K. Metzner, M. J. O'Meara, B. Halligan, J. W. Wotring, J. Z. Sexton, T. R. O'Meara

The paper uses imaging-based screening to identify compounds that inhibit hyphal transition in C. albicans, identifying eIF3 as a target of NSC 697923.

bioRxiv · Apr 19, 2023 · PreprintMicrobiology

Ankrd26 is critical for cell differentiation and cancer-linked mutations affect its key properties

S. A. Hofbrucker-MacKenzie, A. S. Englisch, M. Izadi, K. Metzner, M. M. Kessels, B. Qualmann

This study identifies Ankrd26's role in cellular differentiation and shows how cancer-linked mutations disrupt its function and lead to aberrant signaling.

bioRxiv · May 19, 2021 · PreprintCancer Biology