Potent, specific MEPicides for treatment of zoonotic staphylococci
R. L. Edwards, I. Heueck, S. G. Lee, I. T. Shah, A. J. Jezewski, J. J. Miller, M. O. Mikati, X. Wang, R. C. Brothers, K. M. Heidel, C.-A. D. Burnham, S. Alvarez, S. A. Fritz, C. S. Dowd, J. M. Jez, A. R. Odom John
This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.
PLOS Pathogens · Jun 4, 2020Peer-reviewedMicrobiology