Author

A. J. Jezewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Organism:mouse· 2 Organism:plant (other)· 2

Frequent Co-Authors

A. R. Odom John· 5 shared A. M. Guggisberg· 2 shared A. D'Alessandro· 1 shared A. Y. Gandhi· 1 shared C. S. Dowd· 1 shared C.-A. D. Burnham· 1 shared D. Fox· 1 shared D. J. Krysan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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5 shared papersMicrobiology

A. R. Odom John

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Survival in macrophages induces enhanced virulence in Cryptococcus

J. Nielson, A. J. Jezewski, M. Wellington, J. M. Davis

The paper shows that Cryptococcus cells become more virulent after surviving in macrophages, with increased mannose and chitin exposure on their cell walls.

bioRxiv · Sep 3, 2023 · PreprintMicrobiology

Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection

K. M. Alden, A. J. Jezewski, S. R. Beattie, D. Fox, D. J. Krysan

This study identifies multiple acetyl-CoA-generating pathways in Cryptococcus neoformans essential for infection, showing synthetic lethality between ACL1 and ACS1 and reduced fitness in vivo.

bioRxiv · Mar 16, 2022Microbiology

Cooperativity mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites

A. J. Jezewski, A. M. Guggisberg, D. M. Hodge, N. Ghebremichael, L. K. McLellan, A. R. Odom John

This study identifies GAPDH cooperativity as a key factor in FSM resistance and MEP pathway regulation in Plasmodium falciparum.

bioRxiv · Nov 5, 2021 · PreprintMicrobiology

Targeting host glycolysis as a strategy for antimalarial development.

A. J. Jezewski, Y.-H. Lin, J. A. Reisz, R. Culp-Hill, Y. Barekatain, V. C. Yan, A. D'Alessandro, F. L. Muller, A. R. Odom John

The paper investigates enolase inhibitors' effects on erythrocytes and their implications for antimalarial therapy by examining red blood cell homeostasis and parasite growth.

bioRxiv · Oct 9, 2020 · PreprintPharmacology & Toxicology

Potent, specific MEPicides for treatment of zoonotic staphylococci

R. L. Edwards, I. Heueck, S. G. Lee, I. T. Shah, A. J. Jezewski, J. J. Miller, M. O. Mikati, X. Wang, R. C. Brothers, K. M. Heidel, C.-A. D. Burnham, S. Alvarez, S. A. Fritz, C. S. Dowd, J. M. Jez, A. R. Odom John

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

PLOS Pathogens · Jun 4, 2020Peer-reviewedMicrobiology

Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites

E. S. Mathews, A. J. Jezewski, A. R. Odom John

This study identifies farnesylation of HSP40 as essential for thermotolerance and vesicular trafficking in Plasmodium falciparum.

bioRxiv · Nov 14, 2019Microbiology

Suppression of drug resistance reveals a genetic mechanism of metabolic plasticity in malaria parasites

A. M. Guggisberg, P. M. Frasse, A. J. Jezewski, N. M. Kafai, A. Y. Gandhi, S. J. Erlinger, A. R. Odom John

The paper identifies a genetic mechanism of metabolic plasticity in malaria parasites by uncovering HAD2 as a phosphatase regulating drug resistance and PFK9 as a suppressor of resistance.

bioRxiv · Jun 18, 2018Microbiology