Author

C.-A. D. Burnham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:database / resource· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. R. Odom John· 2 shared C. S. Dowd· 2 shared I. T. Shah· 2 shared J. J. Miller· 2 shared K. M. Heidel· 2 shared M. O. Mikati· 2 shared R. L. Edwards· 2 shared A. J. Jezewski· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. R. Odom John

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice

A. Rosen, M. Lint, D. Voelker, N. Gilbert, C. Tomera, J. Santiago Borges, M. A. Wallace, T. Hannan, C.-A. D. Burnham, S. Hultgren, A. Kau

This study shows that SLPI protects against acute UTI in mice and suggests SLPI is regulated in response to uropathogen exposure in women.

mBio · Feb 14, 2024Peer-reviewedImmunology

Multi-omics investigation of Clostridioides difficile-colonized patients reveals protective commensal carbohydrate metabolism

S. R. S. Fishbein, J. I. Robinson, T. Hink, K. A. Reske, E. P. Newcomer, C.-A. D. Burnham, J. P. Henderson, E. R. Dubberke, G. Dantas

This study identifies carbohydrate metabolism by commensal Clostridia as protective against C. difficile infection in asymptomatic carriers.

bioRxiv · Aug 24, 2021Microbiology

Antimicrobial prodrug activation by the staphylococcal glyoxalase GloB

M. O. Mikati, J. J. Miller, D. M. Osbourn, N. Ghebremichael, I. T. Shah, C.-A. D. Burnham, K. M. Heidel, V. C. Yan, F. L. Mueller, C. S. Dowd, R. L. Edwards, A. R. Odom John

This study identifies GloB as a bacterial enzyme that activates carboxy ester prodrugs, suggesting its potential for developing targeted prodrug therapies against staphylococcal species.

ACS Infectious Diseases · Oct 29, 2020Peer-reviewedMicrobiology

Potent, specific MEPicides for treatment of zoonotic staphylococci

R. L. Edwards, I. Heueck, S. G. Lee, I. T. Shah, A. J. Jezewski, J. J. Miller, M. O. Mikati, X. Wang, R. C. Brothers, K. M. Heidel, C.-A. D. Burnham, S. Alvarez, S. A. Fritz, C. S. Dowd, J. M. Jez, A. R. Odom John

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

PLOS Pathogens · Jun 4, 2020Peer-reviewedMicrobiology

Improving characterization of understudied human microbiomes using targeted phylogenetics

B. A. Rosa, K. Mihindukulasuriya, K. Hallsworth-Pepin, A. Wollam, J. Martin, C. Snowden, W. M. Dunne, G. Weinstock, C.-A. D. Burnham, M. Mitreva

The paper improves mapping of metagenomic reads from under-represented body sites by sequencing and assembling 665 new bacterial genomes, increasing read mapping rates for the Human Microbiome Project samples.

mSystems · Feb 11, 2020Peer-reviewedMicrobiology