Author

I. Lemersal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

C. G. Towers· 1 shared C. R. Schiavon· 1 shared D. A. Grotjahn· 1 shared G. R. Rojas· 1 shared G. S. Shadel· 1 shared J. A. Chevez· 1 shared L. E. Newman· 1 shared M. Medina· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

C. G. Towers

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1 paper

Recent·Most cited

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

L. E. Newman, N. Tadepalle, S. W. Novak, C. R. Schiavon, G. R. Rojas, J. A. Chevez, I. Lemersal, M. Medina, S. Rocha, C. G. Towers, D. A. Grotjahn, U. Manor, G. S. Shadel

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

bioRxiv · Oct 12, 2022 · PreprintCell Biology