Author

C. R. Schiavon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

U. Manor· 5 shared G. S. Shadel· 2 shared M. Wu· 2 shared T. Zhang· 2 shared A. M. Santos· 1 shared A. Malhotra· 1 shared A. O. Souza· 1 shared A. Saghatelian· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCell Biology

U. Manor

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Author profile →

5 papers

Recent·Most cited

Mitochondria- and ER-associated actin are required for mitochondrial fusion

P. Gatti, C. R. Schiavon, U. Manor, M. Germain, J. Cicero

The paper shows that actin filaments on mitochondria and ER are required for both fission and fusion, with Arp2/3 and INF2 playing distinct roles in fusion.

bioRxiv · Jun 13, 2023Cell Biology

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

L. E. Newman, N. Tadepalle, S. W. Novak, C. R. Schiavon, G. R. Rojas, J. A. Chevez, I. Lemersal, M. Medina, S. Rocha, C. G. Towers, D. A. Grotjahn, U. Manor, G. S. Shadel

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

Y. Lei, J. Zhang, C. R. Schiavon, M. He, L. Chen, H. Shen, Y. Zhang, Q. Yin, Y. Cho, L. Andrade, G. S. Shadel, M. Hepokoski, T. Lei, H. Wang, J. Zhang, , J. Y.-J. Shyy

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

bioRxiv · Dec 4, 2020Pathology

Actin chromobody imaging reveals sub-organellar actin dynamics

C. R. Schiavon, T. Zhang, B. Zhao, L. R. Andrade, M. Wu, T.-C. Sung, Y. Dayn, J. W. Feng, O. A. Quintero, R. Grosse, U. Manor

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.

bioRxiv · Jun 25, 2019Cell Biology

A novel role for Myosin-Va in mitochondrial fission

J. S. Araujo, R. M. P. Silva-Junior, T. Zhang, C. R. Schiavon, Q. Chu, M. Wu, C. L. S. Pontes, A. O. Souza, L. C. Alberici, A. M. Santos, S. B. Ingle, A. Saghatelian, J. Spudich, U. Manor, E. M. Espreafico

This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.

bioRxiv · May 31, 2019 · PreprintCell Biology