Author

D. A. Grotjahn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:clustering· 1

Frequent Co-Authors

B. A. Barad· 2 shared M. Medina· 2 shared A. A. Deniz· 1 shared B. Basanta· 1 shared C. G. Towers· 1 shared C. R. Schiavon· 1 shared D. Fuentes· 1 shared D. Park· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

B. A. Barad

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Author profile →

6 papers

Recent·Most cited

Reentrant DNA shells tune polyphosphate condensate size

R. Chawla, J. K. A. Tom, T. Boyd, D. A. Grotjahn, D. Park, A. A. Deniz, L. R. Racki

This study investigates how DNA interacts with polyphosphate-Mg2+ condensates, showing DNA forms reentrant shells that regulate condensate size and DNA structure.

bioRxiv · Sep 13, 2023Biophysics

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

L. E. Newman, N. Tadepalle, S. W. Novak, C. R. Schiavon, G. R. Rojas, J. A. Chevez, I. Lemersal, M. Medina, S. Rocha, C. G. Towers, D. A. Grotjahn, U. Manor, G. S. Shadel

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

B. A. Barad, M. Medina, D. Fuentes, R. L. Wiseman, D. A. Grotjahn

The paper introduces a surface morphometrics toolkit for quantifying organellar membrane ultrastructure using cryo-ET, showing ER stress induces adaptive mitochondrial ultrastructural remodeling.

bioRxiv · Jan 23, 2022Cell Biology

Nanoscale details of mitochondrial fission revealed by cryo-electron tomography

S. K. Mageswaran, D. A. Grotjahn, X. Zeng, B. A. Barad, M. A. Medina, M. H. Hoang, M. J. Dobro, Y.-W. Chang, M. Xu, W. Y. Yang, G. J. Jensen

This study uses cryo-electron tomography to reveal nanoscale details of mitochondrial fission in mammalian cells, showing coordinated membrane constriction and the role of actin and septin filaments.

bioRxiv · Dec 13, 2021 · PreprintCell Biology

A case for glycerol as an acceptable additive to cryoEM samples

B. Basanta, M. Hirschi, D. A. Grotjahn, G. C. Lander

This study shows glycerol can be used as a cryoEM sample additive without compromising high-resolution structure determination, using mouse apoferritin and rabbit muscle aldolase as examples.

bioRxiv · Sep 10, 2021Biophysics

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

D. A. Grotjahn, S. Chowdhury, Y. Xu, R. J. McKenney, T. Schroer, G. Lander

The paper uses cryo-electron tomography to reveal the 3D structure of the dynein-dynactin complex bound to microtubules, showing how dynactin recruits two dynein dimers for processive motility.

bioRxiv · Aug 31, 2017Cell Biology