Author

I. M. Boekhoud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

W. K. Smits· 3 shared E. J. Kuijper· 2 shared I. M. J. G. Bos-Sanders· 2 shared A.-M. Michel· 1 shared B. Spittal· 1 shared C. Harmanus· 1 shared COMBACTE-CDI Consortium· 1 shared D. Jahn· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

W. K. Smits

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Author profile →

3 papers

Recent·Most cited

Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of C. difficile

I. M. Boekhoud, I. Sidorov, S. Nooij, C. Harmanus, I. M. J. G. Bos-Sanders, V. Viprey, B. Spittal, E. Clark, K. Davies, J. Freeman, E. J. Kuijper, W. K. Smits, COMBACTE-CDI Consortium, European Study Group for Clostridioides difficile

The paper shows heme dependence in metronidazole resistance in C. difficile clinical isolates, linked to a SNP in hsmA and associated with a resistant lineage.

bioRxiv · Nov 18, 2020Microbiology

Redefining the Clostridioides difficile σB regulon: σB activates genes involved in detoxifying radicals that can result from the exposure to antimicrobials and hydrogen peroxide

I. M. Boekhoud, A.-M. Michel, J. Corver, D. Jahn, W. K. Smits

This study identifies genes directly regulated by σB in C. difficile and shows that antimicrobials and hydrogen peroxide induce these genes via σB-dependent mechanisms.

bioRxiv · Jul 16, 2020Microbiology

Genome location dictates the transcriptional response to PolC-inhibition in Clostridium difficile

E. van Eijk, I. M. Boekhoud, E. J. Kuijper, I. M. J. G. Bos-Sanders, G. Wright, W. K. Smits

This study shows that genome location influences the transcriptional response to PolC-inhibition in C. difficile, with origin-proximal genes being more upregulated.

bioRxiv · Sep 21, 2018Microbiology