Author

C. Harmanus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

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Organism:C. elegans· 4 Approach:experimental assay· 4 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

W. K. Smits· 5 shared E. J. Kuijper· 4 shared B. V. H. Hornung· 2 shared I. M. J. G. Bos-Sanders· 2 shared Q. R. Ducarmon· 2 shared R. H. A. M. Vossen· 2 shared S. L. Kloet· 2 shared A. C. Fluit· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersMicrobiology

W. K. Smits

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5 papers

Recent·Most cited

Clostridioides difficile PCR ribotype 151 is polyphyletic and includes pathogenic isolates from cryptic clade C-II with mono-toxin pathogenicity loci that can escape routine diagnostics

Q. R. Ducarmon, T. van der Bruggen, C. Harmanus, I. M. J. G. Sanders, L. G. M. Daenen, A. C. Fluit, R. H. A. M. Vossen, S. L. Kloet, E. J. Kuijper, W. K. Smits

The paper identifies that PCR ribotype 151 of Clostridioides difficile is polyphyletic, includes both non-toxigenic and toxigenic isolates, and contains pathogenic variants that evade routine diagnostics.

bioRxiv · Aug 17, 2022 · PreprintMicrobiology

Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile

A. M. Roseboom, Q. R. Ducarmon, B. V. H. Hornung, C. Harmanus, M. J. T. Crobach, E. J. Kuijper, R. H. A. M. Vossen, S. L. Kloet, W. K. Smits

The paper describes a C. difficile clinical isolate carrying three compatible plasmids and identifies functional replicons in two of them.

bioRxiv · Jul 10, 2022Microbiology

Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of C. difficile

I. M. Boekhoud, I. Sidorov, S. Nooij, C. Harmanus, I. M. J. G. Bos-Sanders, V. Viprey, B. Spittal, E. Clark, K. Davies, J. Freeman, E. J. Kuijper, W. K. Smits, COMBACTE-CDI Consortium, European Study Group for Clostridioides difficile

The paper shows heme dependence in metronidazole resistance in C. difficile clinical isolates, linked to a SNP in hsmA and associated with a resistant lineage.

bioRxiv · Nov 18, 2020Microbiology

Plasmid-mediated metronidazole resistance in Clostridioides difficile

I. Boekhoud, B. V. H. Hornung, A. E. Sevilla Romeo, C. Harmanus, I. M. J. G. Bos-Sanders, E. Terveer, R. Bolea, J. Corver, E. J. Kuijper, W. K. Smits

This paper identifies a plasmid, pCD-METRO, as the first reported cause of plasmid-mediated metronidazole resistance in Clostridioides difficile, showing its global dissemination and horizontal transfer potential.

bioRxiv · May 29, 2019Microbiology

A helicase-containing module defines a family of pCD630-like plasmids in Clostridium difficile

W. K. Smits, J. S. Weese, A. P. Roberts, C. Harmanus, B. Hornung

This study identifies a family of pCD630-like plasmids in Clostridium difficile defined by a conserved helicase and reports two sub-groups differing in size and accessory modules.

bioRxiv · Nov 2, 2017Microbiology