I. M. N. Wortel

The paper uses machine learning to identify TCR sequence features predicting self-reactivity, finding that n-nucleotide additions and acidic amino acids reduce self-reactivity.

This paper shows that T cell search strategies may arise from physical constraints rather than evolutionary adaptation, using simulations to demonstrate that optimal motion patterns can emerge as side effects of cellular mechanics.

This study shows that Listeria motility enhances goblet cell invasion during intestinal infection by improving target cell engagement and invasion efficiency.

This paper shows that a Cellular Potts Model of cell migration spontaneously reproduces the universal speed-persistence coupling without being designed for it.

The paper shows that negative T cell selection on non-random peptides enables robust self-nonself discrimination despite incomplete silencing of self-reactive cells.