Author

I. Nathke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

I. P. Newton· 4 shared A. J. Langlands· 1 shared A. R. Prescott· 1 shared A. Rojaa· 1 shared B. F. Cox· 1 shared E. Clutton· 1 shared F. Stewart· 1 shared G. Cummins· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

I. P. Newton

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Ultrasound Mediated Delivery of Quantum Dots from a Capsule Endoscope to the Gastrointestinal Wall

F. Stewart, G. Cummins, M. V. Turcanu, B. F. Cox, A. R. Prescott, E. Clutton, I. P. Newton, M. P. Y. Desmulliez, M. Thanou, H. Mulvana, S. Cochran, I. Nathke

This paper demonstrates a capsule device that uses focused ultrasound and microbubbles to deliver fluorescent markers through the mucus layer of the porcine small intestine.

bioRxiv · Feb 24, 2020Bioengineering

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Y. Chen, I. P. Newton, M. Vandereyken, I. Moraga, I. Nathke, M. Swamy

This study shows that loss of Apc function in intestinal epithelial cells reduces IL-22 receptor expression and STAT3 activation, leading to resistance to IL-22 and increased genetic instability.

bioRxiv · Dec 1, 2018Immunology

Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomics

O. Popow, M. Tatham, J. Paulo, A. Rojaa, N. Loyer, I. P. Newton, J. Januschke, K. Haigis, I. Nathke

The paper identifies APC interaction partners and β-catenin-independent targets using proteomics, revealing MINK1 as a potential substrate of an alternative APC destruction complex.

bioRxiv · Feb 1, 2018Cancer Biology

Postmitotic Separation Enables Selective Niche Retention Of One Daughter Cell In Intestinal Crypts And Is Facilitated By Interkinetic Nuclear Migration And Basal Tethering

T. Carroll, A. J. Langlands, J. M. Osborne, I. P. Newton, P. L. Appleton, I. Nathke

The paper shows that postmitotic separation of intestinal crypt cells leads to niche retention of one daughter cell, and this process is disrupted in Apc mutant cells.

bioRxiv · May 26, 2017Cancer Biology