Author

I. Rosas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Negro· 2 shared B. Gel Moreno· 2 shared E. Castellanos· 2 shared E. Serra· 2 shared H. Mazuelas· 2 shared I. Blanco· 2 shared M. Carrio· 2 shared A. Papi· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

A. Negro

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unbalancing cAMP and Ras/MAPK pathways as a therapeutic strategy for cutaneous neurofibromas

H. Mazuelas, M. Magallon-Lorenz, I. Uriarte-Arrazola, A. Negro, I. Rosas, I. Blanco, E. Castellanos, C. Lazaro, B. Gel Moreno, M. Carrio, E. Serra

This study identifies a therapeutic strategy for cutaneous neurofibromas by combining a MEKi and a cAMP elevator to disrupt SC-FB crosstalk and inhibit tumor growth.

JCI Insight · Feb 8, 2024Peer-reviewedCancer Biology

MERLIN-DEFICIENT iPSCs AS AN IN VITRO MODEL SYSTEM FOR STUDIYNG NF2 PATHOGENESIS

N. Catasus, M. Torres-Martin, A. Negro, B. Kuebler, I. Rosas, G. Casals, H. Mazuelas, F. Roca-Ribas, E. Amilibia, B. Aran, A. Veiga, A. Raya, B. Gel Moreno, I. Blanco, E. Serra, , E. CASTELLANOS

The paper generates and characterizes NF2-deficient iPSCs to study NF2 pathogenesis, showing they can model merlin-deficient Schwann cell features in vitro.

bioRxiv · Dec 14, 2022 · PreprintCell Biology

Tocilizumab treatment leads to early resolution of lymphopenia and myeloid dysregulation in patients hospitalized with COVID-19

H. Shivram, J. A. Hackney, C. M. Rosenberger, A. Teterina, A. Qamra, O. Onabajo, J. McBride, F. Cai, M. Bao, L. Tsai, A. Regev, I. Rosas, R. Bauer

bioRxiv · Oct 27, 2022 · PreprintImmunology

Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection

C. X. Yang, M. Tomchaney, M. F. Landecho, B. Recalde, M. M. Oto, J. Zulueta, J. Malo, S. Knoper, M. Contoli, A. Papi, D. Vasilescu, M. Sauler, C. Straub, C. Tan, F. D. Martinez, , F. Polverino

The paper uses spatial transcriptomic and proteomic profiling to analyze lung tissues from COPD patients who died of COVID-19, revealing increased T-lymphocytes and altered immune responses.

bioRxiv · Apr 20, 2022Immunology

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

E. A. Ayaub, S. Poli, J. Ng, T. S. Adams, J. C. Schupp, L. Quesada, F. Poli, C. Cosme, R. Matthew, J. Martinez, X. Liang, J. Villalba, J. A. Lederer, S. G. Chu, B. Raby, , I. Rosas

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

bioRxiv · Jan 4, 2021 · PreprintCell Biology