T. S. Adams

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.

In vitro engineering of the lung alveolus

This study develops an in vitro strategy to engineer lung alveoli by coordinating biochemical, cellular, and mechanical cues to differentiate alveolar epithelial cells.

Microenvironmental sensing by fibroblasts controls macrophage population size

This study shows fibroblasts sense space and regulate macrophage numbers via growth factor production.

High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

The paper analyzes single-cell transcriptomes from healthy and chronic lung disease lungs to identify gene expression programs linked to SARS-CoV-2 entry and severity.

Airway Basal Cells show a dedifferentiated KRT17high Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

This study identifies IPF-ABC as dedifferentiated KRT17high cells that promote fibrosis and shows SRC inhibition can reverse their profibrotic effects.