Protein hyperacylation links mitochondrial dysfunction with nuclear organization
J. A. Smestad, M. McCauley, M. Amato, Y. Xiong, J. Liu, Y.-C. Sin, J. Ellingson, Y. Chen, F. Al Khazal, B. Wilbanks, J.-H. Lee, T. Ordog, I. Rouzina, M. C. Williams, J. Locasale, L. J. Maher
This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.
bioRxiv · Oct 23, 2020 · PreprintCell Biology