Author

J. Locasale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Liu· 2 shared A. Allen· 1 shared A. B. M. M. K. Islam· 1 shared A. V. Kabanov· 1 shared B. Wilbanks· 1 shared C. Lim· 1 shared C. W. McCloskey· 1 shared D. E. Cooper· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

J. Liu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

M. B. Eduardo, G. Cottone, C. W. McCloskey, S. Liu, M. P. Zappia, E. V. Benevolenskaya, A. B. M. M. K. Islam, M. V. Frolov, F. R. Palma, P. Gao, J. Setya, H. Gao, X. Xuei, R. Khokha, J. Locasale, , S. E. Clare

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

bioRxiv · Feb 21, 2024 · PreprintCancer Biology

Nucleotide metabolism is linked to cysteine availability

A. Allen, Y. Sun, F. Wei, M. A. Reid, J. Locasale

This study investigates how erastin and other ferroptosis inducers affect global metabolism, finding that nucleotide metabolism is significantly impacted and linked to cysteine availability.

bioRxiv · Sep 30, 2022Cell Biology

13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo

L. Duan, D. E. Cooper, G. Scheidemantle, J. Locasale, D. G. Kirsch, X. Liu

This study uses 13C tracing to show that endogenous CO2 recycling is significant in vivo, affecting isotopologue distribution and providing insights for metabolic studies.

bioRxiv · Feb 4, 2021 · PreprintBiochemistry

Protein hyperacylation links mitochondrial dysfunction with nuclear organization

J. A. Smestad, M. McCauley, M. Amato, Y. Xiong, J. Liu, Y.-C. Sin, J. Ellingson, Y. Chen, F. Al Khazal, B. Wilbanks, J.-H. Lee, T. Ordog, I. Rouzina, M. C. Williams, J. Locasale, L. J. Maher

This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.

bioRxiv · Oct 23, 2020 · PreprintCell Biology

Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway

I. Shats, J. Liu, J. G. Williams, L. J. Deterding, C. Lim, E. Lee, W. Fan, M. Sokolsky, A. V. Kabanov, J. Locasale, X. Li

This paper shows bacteria enhance mammalian NAD metabolism by using a deamidated biosynthesis pathway, contributing to drug resistance and improving NAD-boosting efficiency.

bioRxiv · Dec 7, 2018Biochemistry