Author

M. C. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Meeske· 2 shared L. J. Maher· 2 shared S. R. Margolis· 2 shared A. A. S. Tavares· 1 shared A. E. Reker· 1 shared A. J. Drake· 1 shared A. Kozlova· 1 shared A. Lovdel· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

A. J. Meeske

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diverse viral cas genes antagonize CRISPR immunity

M. A. Katz, E. M. Sawyer, A. Kozlova, M. C. Williams, S. R. Margolis, L. Oriolt, M. Johnson, J. Bondy-Denomy, A. J. Meeske

The paper identifies novel anti-CRISPR genes in Listeria isolates that antagonize diverse CRISPR-Cas systems, revealing evolutionary mechanisms of Acrs through cas gene co-option.

bioRxiv · Jun 24, 2023Microbiology

Phage genome cleavage enables resuscitation from Cas13-induced bacterial dormancy

M. C. Williams, A. E. Reker, S. R. Margolis, J. Liao, M. Wiedmann, E. R. Rojas, A. J. Meeske

This study shows that type VI CRISPR systems and DNA-cleaving restriction modification systems work together to eliminate phage DNA and neutralize infection in Listeria seeligeri.

bioRxiv · Jul 5, 2022Microbiology

Protein hyperacylation links mitochondrial dysfunction with nuclear organization

J. A. Smestad, M. McCauley, M. Amato, Y. Xiong, J. Liu, Y.-C. Sin, J. Ellingson, Y. Chen, F. Al Khazal, B. Wilbanks, J.-H. Lee, T. Ordog, I. Rouzina, M. C. Williams, J. Locasale, L. J. Maher

This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.

bioRxiv · Oct 23, 2020 · PreprintCell Biology

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in systemic glucose homeostasis

K. J. Suchacki, A. A. S. Tavares, D. Mattiucci, E. L. Scheller, G. Papanastasiou, C. Gray, M. C. Sinton, L. E. Ramage, W. A. McDougald, A. Lovdel, R. J. Sulston, B. J. Thomas, B. M. Nicholson, A. J. Drake, C. Alcaide-Corral, , W. P. Cawthorn

This study identifies bone marrow adipose tissue (BMAT) as a distinct adipose subtype with unique metabolic functions in glucose homeostasis.

bioRxiv · Jun 18, 2019Physiology

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

A. Uchida, D. Murugesapillai, Y. Wang, M. F. Lodeiro, S. Prabhakar, J. Arnold, L. J. Maher, M. C. Williams, C. E. Cameron

The paper identifies sequences and structural requirements for efficient transcription from the first heavy-strand promoter in mtDNA, highlighting the role of TFAM's carboxy-terminal tail and HVR3.

bioRxiv · Apr 24, 2017Biochemistry