Q. Qiu

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

This study shows that antiviral drugs fail to prevent neurological deficits in SARS-CoV-2-infected mice, which resemble neurodegenerative diseases due to chronic inflammation.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node Metastasis

This study shows that tumor-derived extracellular vesicles induce neutrophil extracellular traps in lymph nodes, promoting metastasis and identifying potential therapeutic targets.

The Mechanism underlying B cell Developmental Dysfunction in Kawasaki Disease Based on Single-cell Transcriptomic Sequencing

This study uses single-cell transcriptomics to identify B cell developmental dysfunction in Kawasaki Disease, showing repression of immune processes and altered gene expression in HSPCs and B cells before treatment.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

β-Coronaviruses use lysosomal organelles for cellular egress.

This study shows β-coronaviruses exit cells via lysosomal trafficking, not the secretory pathway, and identifies Arl8b as a regulator of this process.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.