I. Sonntag

CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-B pathway

This study shows that loss of CFH in RPE cells increases inflammation and disrupts complement regulation via the NF-κB pathway, contributing to AMD pathology.

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

This study shows that loss of Complement Factor H in human RPE cells reduces antioxidant capacity and impairs energy metabolism, contributing to AMD pathogenesis.