S. J. Clark

A fungal endophyte induces local cell-wall mediated resistance in wheat roots against take-all disease

FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture model

This study shows that loss of FH in RPE cells causes retinal degeneration in a co-culture model with porcine retinal explants, with rod cells being the first to degenerate.

CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-B pathway

This study shows that loss of CFH in RPE cells increases inflammation and disrupts complement regulation via the NF-κB pathway, contributing to AMD pathology.

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

This study shows FHL-1 protects RPE cells from oxidative stress via α5β1 integrin interaction, with increased heat-shock protein expression and improved cell survival.

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

This study shows that loss of Complement Factor H in human RPE cells reduces antioxidant capacity and impairs energy metabolism, contributing to AMD pathogenesis.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.